Knee anatomy diagram

MSM “Miracle pain reliever”

  • Muscle and skeleton pain relief
  • Anti-inflammatory agent
  • 34% sulfur: clear acne, heal wounds, strengthen skin, and antioxidation
  • Maintain healthy joints, cartilage, bones, synovial membranes, and skin
  • Support keratin protein synthesis and collagen protein synthesis

An organosulfur compound, sulfur the “beauty mineral.”

Methylsulfonylmethane (MSM) is a naturally occurring organosulfur compound found in plants. Sulfur, the third most abundant mineral in humans exerts a myriad of bodily effects and regulations, including; fighting radiation exposure, clearing acne, healing wounds, strengthening skin (reducing dandruff), dilation of dermal vessels, cartilage support, anti-inflammation, antioxidant effects, bone repair, synovial fluid health, various metabolic pathways and functions, and keratin protein synthesis [1, 5].

34% of methylsulfonylmethane is comprised of sulfur [5]. MSM as a dietary compound in the body exerts its own specific health benefits, namely; hyperacidity therapy, muscle and skeleton pain therapy, constipation alleviation, arthritis and osteoarthritis aid, anti-inflammatory effects, reduction of joint pain, increased joint flexibility, antioxidant effects, joint degeneration treatment, and complete skin and dermal layers support [1, 2, 3, 4, 5, 6].
MSM is an entirely safe dietary compound as well, in all of biochemistry it is one of the least toxic molecules, it is about the same as water in that regard [5].

Exercise, especially high intensity exercise can cause joint and muscle pain. In a 2017 double-blind, placebo-controlled clinical trial, researchers concluded that oral MSM supplementation has clinical joint and muscle pain reduction value [6].

MSM is biologically capable of crossing cell membranes, and can also act as a membrane transport molecule. Sulfur which MSM provides is also necessary for cell permeability. Sulfur has been celebrated as the “beauty mineral.” Foods high in sulfur include, brussel sprouts, legumes, garlic, onions, organic pasture raised chicken eggs, asparagus, wheat germ, liver, parmesan, peaches, bonk choy, and kale. Show moreHide Text...


  • Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients, 9(3), 290. doi:10.3390/nu9030290
  • Debbi, E., Agar, G., Fichman, G., Ziv, Y., Kardosh, R., Halperin, N., . . . Debi, R. (2011). Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: A randomized controlled study. BMC Complementary and Alternative Medicine, 11(1), 50.
  • Kim, Axelrod, Howard, Buratovich, & Waters. (2006). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: A pilot clinical trial. Osteoarthritis and Cartilage, 14(3), 286-294.
  • Nakhostin‐Roohi, B., Barmaki, S., Khoshkhahesh, F., & Bohlooli, S. (2011). Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. Journal of Pharmacy and Pharmacology, 63(10), 1290-1294.
  • Parcell, Stephen W. (2002). Sulfur in human nutrition and applications in medicine. (Review: Sulfur). Alternative Medicine Review, 7(1), 22-44.
  • Withee, Eric D., Tippens, Kimberly M., Dehen, Regina, Tibbitts, Deanne, Hanes, Douglas, & Zwickey, Heather. (2017). Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: A double-blind, randomized, placebo-controlled trial. Journal of the International Society of Sports Nutrition, 14(1), 1-11.