Amino acid L-Serine chemical structure

L-Serine Healthy Metabolism

  • Metabolize fats & fatty acids
  • Aid Glutathione peroxidase production
  • Support nervous system (protects myelin sheaths)
  • Produce antibodies
  • Support cell adhesion molecules

Conditionally essential (during times of cellular demand) Organic amino acid

L-Serine maintains a harmonious relationship with P-selectin protein coded by the SelP gene. P-selectin proteins are cell adhesion molecules, responsible for reacting to injury sites. Mobilizing leukocytes (white blood cells) to inflammation areas, and controlling blood aggregates. L-Serine is very important for maintaining positive metabolic activity, mental health, and nervous system functioning. 

L-Serine also shares a symbiotic relationship with Glutathione Peroxidase (GPx) a strong Antioxidant enzyme, with significant anti aging qualities. GPx is a key agent against Reactive Oxygen Species (ROS), GPx antioxidant activity regulates and fights oxidative stress and free radicals that damage cells.
The theory of GPx is: levels of GPx enzyme decrease with age, leaving the body more susceptible to increased free radicals (oxidative stressors), consequently allowing aging to accelerate, meaning GPx antioxidant is a vital nutrient to encourage healthy aging

L-Serine also serves cytoprotective processes, i.e., protecting cells from stress, and damage. Studies have also indicated that L-Serine can protect the skin from UV radiation, by serving as an iron-chelator antioxidant. Aiding healthy looking, and feeling skin. Show moreHide Text...

Sources

  • De Koning, T. J., Snell, K., Duran, M., Berger, R., Poll-The, B.-T., & Surtees, R. (2003). L-serine in disease and development. Biochemical Journal, 371(Pt 3), 653–661.
  • Espinoza, S. E., Guo, H., Fedarko, N., DeZern, A., Fried, L. P., Xue, Q.-L., … Walston, J. D. (2008). Glutathione Peroxidase Enzyme Activity in Aging. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63(5), 505–509. https://academic.oup.com/biomedgerontology/article/63/5/505/590630/Glutathione-Peroxidase-Enzyme-Activity-in-Aging#.WYoDNYHrURs.
  • Maralani, M. , Movahedian, A. , & Javanmard, S. (2012). Antioxidant and cytoprotective effects of l-serine on human endothelial cells. Research in Pharmaceutical Sciences, 7(4), 209-215. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523412/
  • National Center for Biotechnology Information. PubChem Compound Database; CID=5951, https://pubchem.ncbi.nlm.nih.gov/compound/5951 (accessed Sept. 18, 2017).
  • Viña, J. , Tarazona-Santabalbina, F. , Pérez-Ros, P. , Martínez-Arnau, F. , Borras, C. , et al. (2016). Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function. Molecular Aspects of Medicine, 50, 88-108.
  • Wang, Q. , Sun, L. , Liu, Y. , Lu, J. , Han, F. , et al. (2016). The synergistic effect of serine with selenocompounds on the expression of selp and gpx in hepg2 cells. Biological Trace Element Research, 173(2), 291-296.