Model for hyaluronic acid skin care

Hyaluronic Acid Refreshingly hydrated skin and joints

  • Reduce wrinkle depth and fine lines
  • Reduce skin dryness (face and body)
  • Hydrate joints and skin
  • Maintain healthy joints, cartilage, bone, tendons, and ligaments
  • Synovial fluid viscosity molecule

A biological lubricant macromolecule. Naturally refresh and hydrate aging skin and joints.

A naturally occurring macromolecule in cartilage, skin, and synovial fluid. Hyaluronic acid absorbs 1000 times its weight in water and is responsible for skin and joint hydration. Hyaluronic acid provides viscosity to synovial fluid and is found among collagen fibrils in every dermal layer. The molecule stays in the skin to collect water, hydrating skin cells and providing moisture to the slippery synovial fluid that cushions joints, cartilage, and bone connections. Hyaluronic acid as a consumer product provides the ability to modulate bodily hydration at critical points and regulate extrinsic and intrinsic skin aging.


Hyaluronic acid naturally arises in cartilage, where it decreases inflammation by increasing anti-inflammatory molecular activity. Cartilage resides on the edges of bones as a cushion for joints, tendons, and bones. With age the gradual decline in hyaluronic acid leads to the degradation of cartilage, joints, bone strength, tissue health, and synovial membranes that depend on its availability. In clinical trials dating back to 1988, supplementation of hyaluronic acid has been shown to lower inflammation among at risk populations of osteoarthritis patients [4, 8].


Hyaluronic acid may also be capable of regenerating cartilage, or serving as a catalyst for its rebuilding. Osteoarthritis, a degenerative joint disease that can cause functional disability and other symptoms; joint pain, stiffness, muscle pain, bone aches, decreased flexibility, and mobility that affects so many people it accounts for an estimated loss of one half a percent of US GDP [7].


Hyaluronic acid is being studied and used as a treatment that reduces the symptoms of osteoarthritis because of its ability lubricate joints, muscles, bone, and cartilage, while reducing inflammation [1]. Human clinical trials also show high tolerability for hyaluronic acid supplementation with minimal side effects.


Intrinsic and extrinsic factors cause skin aging. Intrinsically, the natural decrease in hormones and declining moisture rich collagen levels leads to drying skin as we age. Extrinsic factors like photo-aging, UV radiation and lifestyle choices also play a significant role in our skin’s ability retain its healthy glow [2, 6]. Skin aging is a fact of life, yet there are a multitude of methods to reduce the dramatic impact it can have. Oral consumption of hyaluronic acid reaches the deepest dermal layers leading to smoother, moisture rich skin. In double blind, placebo controlled, clinical trials hyaluronic acid supplementation showed increased skin moisture and hydration in the treatment groups [5, 3]. Show moreHide Text...

Sources

  • Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: Evidence from an ex vivo model and randomized, placebo‐controlled clinical trials. Journal of Cosmetic Dermatology, 14(4), 291-301.
  • Bakilan, F., Armagan, O., Ozgen, M., Tascioglu, F., Bolluk, O., & Alatas, O. (2016). Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial/ Diz Osteoartritli Hastalarda Nativ Tip 2 Kollajen Tedavisinin Degerlendirilmesi: Randomize Kontrollü Çalisma. Eurasian Journal of Medicine, 48(2), 95-101.
  • Barnett, M., Combitchi, D., & Trentham, D. (1996). A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis & Rheumatism, 39(4), 623-628.
  • Barnett, M., Kremer, J., St. Clair, E., Clegg, D., Furst, D., Weisman, M., . . . Trentham, D. (1998). Treatment of rheumatoid arthritis with oral type II collagen: Results of a multicenter, double‐blind, placebo‐controlled trial. Arthritis & Rheumatism, 41(2), 290-297.
  • Benito-Ruiz, P., Camacho-Zambrano, M., Carrillo-Arcentales, J., Mestanza-Peralta, M., Vallejo-Flores, C., Vargas-Lpez, S., . . . Zurita-Gavilanes, L. (2009). A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 2009, Vol.60(S2), P.99-113, 60(S2), 99-113.
  • Borumand, Maryam, & Sibilla, Sara. (2015). Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles. Journal of Medical Nutrition and Nutraceuticals, 4(1), 47.
  • Campos Mbg, P. (2015). An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clinical Pharmacology & Biopharmaceutics, 04(03), Clinical Pharmacology & Biopharmaceutics, 2015, Vol.04(03).
  • Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., … Raychaudhuri, S. P. (2009). Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. International journal of medical sciences, 6(6), 312-21.
  • Effects of oral administration of Type II collagen on rheuma. (1993). Science, 261(5129), 1727.
  • Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2013). Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study. Skin Pharmacology and Physiology, 27(1), 47-55.
  • Ricard-Blum S. (2011). The collagen family. Cold Spring Harbor perspectives in biology, 3(1), a004978. doi:10.1101/cshperspect.a004978
  • T, W., L, L., N, C., P, C., K, T., & A, G. (2017). Efficacy of Oral Collagen in Joint Pain - Osteoarthritis and Rheumatoid Arthritis. Journal of Arthritis, 06(02), Journal of Arthritis, 2017, Vol.06(02).