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Die Young and Leave a Pretty Corpus

That was my mother’s maxim, and to be sure she did. It wasn’t as though she had bad habits. She didn’t smoke or drink but her daily diet wasn’t designed to improve her cellular functions either. She ate the foods she liked without much deviation or regard for ensuring healthy aging. 

Unfortunately, her maxim was wrong and if she had been more conscientious she’d of found ways to age gracefully and live much longer. 

 

Fasting Diets

Clearly, your diet influences all aspects of your life. Choosing foods that are low in sugar and starch is good advice. Avoid alcohol, soft drinks (even diet ones) and carbohydrates: rice, flour, bread, pasta and starchy vegetables like corn or potatoes is a great start. 

But, I’d like to offer you something more. Evidence from numerous recent studies have shown that activating adult stem cells and progenitor cells can be an effective means of renewing, repairing or replacing cells that have been damaged by injury or disease (1, 2, 3). Unlike fetal stem cells, adult stem cells and progenitor cells are designed to maintain homeostasis in specialized tissues; pancreas, muscle, liver, lung, brain, kidney, and bone marrow. Other adult stem cells can travel to sites as needed. The challenge of regenerative medicine is to first find these cell niches and then discover how to activate them to protect against the onset of age related diseases. 

In a modern day success, researches at USC have focused on fasting and Fasting-Mimicking Diets (FMD) to promote beta cell regeneration and reverse Type 1 and Type 2 diabetes (2). Today diabetes affects more than 30 million adults in the US, roughly 25% of all adults over the age of 55. Their research, primarily on mice, has demonstrated that regular periods of fasting and FMD promotes the expression of Neurogenin-3 (Ngn3) a gene encoded protein capable of differentiating adult stem cells and progenitor cells in the pancreas into insulin secreting beta cells (2). Their success has shown to reverse beta cell failure in the presence of Type 1 and Type 2 diabetes. And, according to their research this approach suggests that they have found a holistic means to affect similar outcomes in humans.

 

Exercise 

There are as many thoughts about exercise as there are about diet. I find weight bearing routines broken down into three separate sessions; legs, back, and chest optimize results for anyone in a hurry to see progress. To do these correctly, start with the large muscles first, getting them to fatigue enough to allow the next set of smaller muscles to work just as hard. With the right sequence you’ll find strength and definition improve rapidly. For those of you with a little more time there are all sorts of cardio you can incorporate. Virtually any aerobic exercise that increases you heart rate for at least fifteen minutes is ideal. In the gym however, I like anaerobic exercise - short durations of high intensity exercises aimed at burning molecular energy; glucose, and glycogen rather than oxygen to power your muscles. These high intensity, short bursts may last for as little as a minute but lead to enhanced strength, power, and speed. Chere Di Boscio, Editor in Chief of Eluxe Magazine, said “Exercise not only extends your life, but it makes you feel great. It's been known to relieve symptoms of mild depression and help bring on deeper sleep.”

 

Amino Acids Build Proteins

Nearly your entire body is comprised of proteins. These proteins are made from sequences of amino acids that your genes describe. Each of your approximately 37 trillion cells use these instructions to build the proteins that are required to regulate, facilitate, protect, and provide the fundamental structures of life. Amino acids build the most versatile macromolecules in humans. 

Of the twenty-two proteinogenic amino acids, humans must get nine amino acids from their diet and the remaining thirteen can be produced endogenously. Amino acids play a vital role in how we age, what we’re capable of and how well we perform. They support an active metabolism, they fight fatigue, metabolize fats & fatty acids, support your immune system, aid healthy blood flow, help create detoxifying antioxidants while nourishing keratin, collagen, and elastin. 

 

To Live Longer

Fasting, exercise and amino acids provide a surprisingly easy way to take personal control and responsibility for wellness. As a species, we are learning how to use our metabolism, gene expression, exercise, and diet to prevent or reverse minor discomforts and the serious diseases associated with aging.

 

*This is not to be taken as medical advice, or to diagnose, treat, or cure any illness. These statements have not be viewed or approved by the FDA.

 

References

  1. Buono, & Longo. (2018). Starvation, Stress Resistance, and Cancer. Trends in Endocrinology & Metabolism, 29(4), 271-280.
  2. Cheng, Villani, Buono, Wei, Kumar, Yilmaz, . . . Longo. (2017). Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell, 168(5), 775-788.e12.
  3. Elena Lazzeri, Anna Peired, Lara Ballerini and Laura Lasagni (2012). Adult Stem Cells in Tissue Homeostasis and Disease, Current Frontiers and Perspectives in Cell Biology, Prof. Stevo Najman (Ed.), ISBN: 978-953-51- 0544-2, InTech, Available from: http://www.intechopen.com/books/current-frontiers-and-perspectives-in-cell- biology/adult-stem-cells-in-tissue-homeostasis-and-disease 

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