Amino Acids Supplements

All twenty-two proteinogenic amino acids are units in protein structures, your cells need them to construct biochemical proteins. Yet, every amino acid also has its own individual activities. Supplementing your diet with amino acids is for the raw materials needed to make protein and keep sufficient supply in the liver, yet supplementing amino acids also yields other more specific benefits. They can be taken preemptively, or at any time you desire a natural approach to your own needs. For example; those suffering from depression, our bouts of depressive episodes, thoughts, or feelings, may do well with trying the aromatic amino acids; L-Tryptophan, L-Tyrosine, or L-Phenylalanine, all of which have shown efficacy in supporting mental health, because they are precursors to; dopamine, serotonin, melatonin, noradrenaline, adrenaline, and L-DOPA [1, 12, 14, 24].




Benefits + Examples

Nutrition is one of the largest contributors to health and wellness. Amino acids are required in all living organisms, they are the building blocks of biochemical proteins in all cells. In terms of human beings noticing change in association with supplementing amino acids. Depending on the person, their regular diet, lifestyle, age, and choice of supplement. Amino acids exert mental, physical, metabolic, and holistic effects in humans.

Vasodilation; L-Arginine, widely considered the most versatile amino acid, is the sole precursor to the natural vasodilator nitric oxide. A multitude of clinical trials and studies have proven that L-Arginine supplementation can improve blood flow, both systolic and diastolic blood pressure, hypertension, inflammation, and erectile dysfunction [7, 9, 13, 17, 18, 25, 26].

Fight oxidative stress, create antioxidants, and detoxify the body. Many internally produced antioxidants are enzymes, which are proteins, i.e., amino acids structure them [10]. Also, a lot of the antioxidants you consume via diet are proteins, the body has to digest those proteins, break them down to the individual amino acids that structured them, then cells can build new biochemical proteins within the body using those amino acids. One of the most important/powerful antioxidants is the enzyme, glutathione. Found in the mitochondria (cellular energy factory), glutathione seeks out and stops reactive oxygen species (ROS) a consequential byproduct of ATP production [16]. Glutathione is a tripeptide, formed by the three amino acids; l-cysteine, l-glutamate, and l-glycine [8].  

Neurotransmitter production, neuroprotection, and the ability to act as neurotransmitters and transporters. Nitric oxide produced by L-Arginine, acts as a neurotransmitter in the brain that is deeply entwined in the learning and memory mechanisms of the brain [6, 22]. And, aromatic amino acids (phenylalanine, tyrosine, tryptophan, and [with controversy] histidine). The aromatic amino acids are precursors to the monoamine neurotransmitters, namely; adrenaline, dopamine, serotonin, melatonin, and noradrenaline [11]. Dietary intake of the aromatic amino acids, determines the amount of them available in the brain, and the rate at which they synthesize neurotransmitters [11].

Branched chain amino acids (BCAA), valine, leucine, and isoleucine. These three essential amino acids are extremely popular in the weight-lifting, gym-going, and athletic/sports community. Due to the BCAA’s muscle building benefits, lean muscle mass protection, skeletal muscle mass protection, and of course their role in protein synthesis. Also taking free form amino acids is a more readily bioavailable alternative to consuming protein, which inexorably has to be broken down through the digestive tract and returned to the individual amino acid molecules that composed the protein structure.




Side Effects

Amino acids are generally considered safe, yet knowing yourself, any conditions, dietary restrictions, lifestyle choices, or any of other health factors that could have influence over your reaction to supplements of any kind is important. Individuals with sufficient diets, or no reason to add more nutrients in a isolated form to their diets can experience some discomforts. Side effects along the lines of; stomach irritation, bowel irritation, flatulence, stomach/bowel pain, and diarrhea. Again, side effects are usually not very serious in regular cases, yet discussing supplements with a doctor/physician is advised. *These statements have not been evaluated by the Food and Drug Administration. The writing, and supplements alike are not intended to diagnose, treat, cure, or prevent any disease. Also supplements are for people eighteen and older.  




Safety/Potency/Efficacy

Amino acids are naturally occurring molecules, one of the first two molecular groups that composed the first single celled organisms on earth and continue to be fulcrum to all living organisms. Yes, amino acids, and supplementing amino acids is generally considered safe.

Potency; amino acids supplements, along with most other supplements, especially capsule, tablet, and pill supplements have very long shelf lives. Their potency hardly drops in years of storage, assuming the bottle is stored in a room temperature to cooler, dry place.

Supplementing amino acids has proven to be efficient in many clinical trials, and consumers lives. Helping with a myriad of health interests, and beneficial results of taking amino acids supplements.




Conforming to Diets

On the keto diet you can take just the ketogenic amino acids, for protein material supply. And, when you reach ketosis the ketogenic amino acids are converted to ketone bodies.

Fasting, or other restrictive diets can be aided by a more all-encompassing supplement, ensuring you get a direct form of all the necessary dietary nutrients.




References

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  2. Angelos Halaris, John Plietz. (2007). Agmatine: Metabolic pathway and spectrum of activity in brain.(Leading Article). CNS Drugs, 21(11), 885-900.
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  4. Bode-Böger, S. M., Muke, J., Surdacki, A., Brabant, G., Böger, R. H., & Frölich, J. C. (2003). Oral L-arginine improves endothelial function in healthy individuals older than 70 years. Vascular Medicine, 8(2), 77-81. doi:10.1191/1358863x03vm474oa
  5. Chen, Wollman, Chernichovsky, Iaina, Sofer, & Matzkin. (1999). Effect of oral administration of high‐dose nitric oxide donor l‐arginine in men with organic erectile dysfunction: Results of a double‐blind, randomized, placebo‐controlled study. BJU International, 83(3), 269-273.
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  11. Fernstrom, John, & Fernstrom, Madelyn. (2007). Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain1-3. The Journal of Nutrition, 137(6S), 1539S-1547S; discussion 1548S.
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